• In pancreatic islets we found an increase in

  2025-01-17

  

  In pancreatic islets we found an increase in protein expression of leukocyte 12/15-LO that paralleled the metabolic decline characterized by severe hyperglycemia and reduced islet numbers. Similar increase in 12/15-LO expression by Western blot was found in the control mice, which have a normal meta

• Laminin 925-933 basement membrane br Synthetic lethal approa

  2025-01-17

  

  Synthetic lethal approaches In addition to the potential utility of ATM and ATR as chemo- or radiosensitisers, recent studies suggest that such compounds may have single agent activity in certain subsets of patients through induction of synthetic lethality. Two genes are considered synthetically

• It is now well established that the cumulative

  2025-01-17

  

  It is now well established that the cumulative exposure to endogenous estrogens throughout a woman's life, mainly due to her reproductive history, has an impact on the risk of hormone-dependent breast cancer (Lambertini et al., 2016). Prolonged exposure to estrogens in the case of early age at menar

• AG-126 br Conclusion br Acknowledgments The authors extend

  2025-01-17

  

  Conclusion Acknowledgments The authors extend their appreciation to Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University for funding this work through the research project Number (G-2016-2). Introduction L-ornithine is a natural

• It has been proposed that angiotensin II Ang II may

  2025-01-16

  

  It has been proposed that angiotensin II (Ang II) may upregulate COX-2 expression and the subsequent vasoconstrictor prostanoids production through the activation of AT-1 receptors in vascular smooth muscle cells (Hu et al., 2002). Additionally, this peptide is also able to stimulate the generation

• AKT inhibitor VIII Finally microRNAs miRNA seem to play

  2025-01-16

  

  Finally, microRNAs (miRNA) seem to play an important role in AR signaling in BC. Some authors have described a differential AKT inhibitor VIII of miRNAs in AR-positive BCs compared to AR-negative ones. VEGF and mTOR pathways were also reported as implicated in miRNA dysregulation, suggesting a com

• Recent work has detailed the impact

  2025-01-16

  

  Recent work has detailed the impact of genetic thymidylate synthase of AMPK in the liver, revealing only minor phenotypes upon removal in mice (Boudaba et al., 2018). However, these studies very elegantly showed the potential for small molecule-mediated activation of AMPK to elicit large changes in

• In our previous study we showed that

  2025-01-16

  

  In our previous study we showed that normal and cancerous 8351 of kidney exhibit the activity of alcohol dehydrogenase and aldehyde dehydrogenase. Furthermore, the activity of class I ADH isoenzymes and total ADH were significantly higher in cancer tissue than in unchanged renal cells. Moreover, th

• BCATc Inhibitor 2 To assess relative metabolic activity and

  2025-01-16

  

  To assess relative metabolic activity and proliferation of BCATc Inhibitor 2 attached to various substrates we used the MTT assay [29], [30]. In order to compare the metabolic activity of cells under the various conditions irrespective of the number or viability of the cells, we performed a PicoGre

• To further investigate the role of

  2025-01-15

  

  To further investigate the role of cholesterol in the Rh2-induced cytotoxicity, we then focused on the U937 cell line, which is cholesterol auxotroph and considered as a valuable model to study the importance of cholesterol in membrane structure and function (Billheimer et al., 1987), and used the e

• The current findings proved that citral treatment induced mi

  2025-01-15

  

  The current findings proved that citral treatment induced mitochondrial-mediated apoptotic cell death in both HCT116 and HT29 through the p53 and ROS. As such, citral promoted apoptosis as evident by the externalization of PS and dissipation of Δψm at 24h of treatment in HCT116 and HT29 cells. These

• To enhance the accuracy of SEs in eliminating

  2025-01-15

  

  To enhance the accuracy of SEs in eliminating cancer cells, the mAb recognized by specific Brassinolide hormone on tumor cells were fused with SEs. Fab C215 or C242 fused with SEA promoted apoptosis in human colon carcinoma cells via Fas (Dohlsten et al., 1994, Litton et al., 1996). SEB-incorporated

• Interestingly metabolic dysfunction is also observed in

  2025-01-15

  

  Interestingly, metabolic dysfunction is also observed in amyotrophic lateral sclerosis (ALS). Patients and mouse models of familial ALS exhibit higher levels of resting Vinorelbine tartrate expenditure and lower fat-free mass, indicating a hypermetabolic phenotype. Lim et al. (2012) found that redu

• Although AMPK is a negative

  2025-01-15

  

  Although AMPK is a negative regulator of bioenergetic reprogramming in cancer cells, little is known about the role of AMPK in immunometabolism in sepsis. Our current study indicates that AMPKα dysfunction enhances PKM2-dependent aerobic glycolysis, which results in HMGB1 release in macrophages and

• Mistletoe is universal name for various species of parasitic

  2025-01-14

  

  Mistletoe is universal name for various species of parasitic plant which grows attached to and within the branches of host trees such as apple, elm, oak and pine. Mistletoe extract prepared from Viscum album, a species of mistletoe in the family Santalaceae, is generally known as European mistletoe

15997 records 27/1067 page Previous Next First page 上5页 2627282930 下5页 Last page