• br Materials and methods br

  2019-11-13

  

  Materials and methods Results Discussion Approximately 90% of pulmonary emphysema causes are related to smoking and its progression in patients and are characterized by severity levels [5]. Experimental models using CS to induce emphysema are widely used because they resemble the emphysema

• A study profiling chemokine expression in LCLs revealed high

  2019-11-13

  

  A study profiling chemokine expression in LCLs revealed high expression levels of CCR6, CCR7, and CCR10 and low expression of CXCR4 and CXCR5 in EBV immortalized cells. Accordingly, LCLs showed a markedly increase in migration in response to the ligands of CCR6 (CCL20), CC7 (CCL21), and CCR10 (CCL28

• The yeast Rad p radiation sensitive also called

  2019-11-13

  

  The yeast Rad6p (radiation sensitive 6, also called Ubc2) E2 ubiquitin-conjugating enzyme is a member of the highly conserved UBC proteins in eukaryotes (Xu et al., 2009). Rad6p is involved in several cellular processes, including DNA repair, transcriptional activation and silencing, histone ubiquit

• Multiple sequence alignment of the proteins in the

  2019-11-13

  

  Multiple sequence alignment of the proteins in the DGAT1 sub-family shows that there are about 41 conserved amino Calcium Gluceptate residues distributed over seven sequence motifs [74]. Unlike DGAT2, a large number of DGAT1 residues, including a majority of the conserved residues, are found in a l

• LX7101 HCL Data from our in vitro studies using BEAS B cells

  2019-11-12

  

  Data from our in vitro studies using BEAS-2B cells showed a biphasic response of cells to NNK. The initial phase of decrease in CRM1 expression in NNK-exposed cells was observed in our previous study. In this study, we further showed that p-p53 (Thr55) expression was also decreased during this initi

• During mouse embryogenesis RLIM protein is detectable

  2019-11-12

  

  During mouse embryogenesis, RLIM protein is detectable throughout preimplantation development, consistent with its functions in iXCI maintenance. However, in contrast to differentiating ESCs in culture (Figure 2A), RLIM protein levels are downregulated in nuclei of epiblast cells of implanting embry

• Altogether the results of this study demonstrate

  2019-11-12

  

  Altogether, the results of this study demonstrate that peripheral blockade of both ETA and ETB receptors reduces tumor-induced facial heat hyperalgesia and increased spontaneous grooming, without modifying ongoing nociception. It is possible to suggest that bosentan is acting upon both receptors pre

• br Discussion The N terminal domain of DDRs has long

  2019-11-12

  

  Discussion The N-terminal domain of DDRs has long been recognized as a member of the DS superfamily (Johnson et al., 1993, Karn et al., 1993), and its role in collagen binding is understood in atomic detail (Carafoli et al., 2009, Ichikawa et al., 2007). Our crystal structure shows that the secon

• Introduction Ubiquitylation is a post translational modifica

  2019-11-12

  

  Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dysfunctions. Single ubiquiti

• Introduction In vitro synthetic biology has received conside

  2019-11-12

  

  Introduction In vitro synthetic biology has received considerably less attention than in vivo processes so far (Foster and Church, 2007). However, cell-free biosynthetic production is very likely to become important for many biotechnological challenges for reasons such as (energy) efficiency, syste

• The first transcription factor TF

  2019-11-12

  

  The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone cccp mitochondria of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed dev

• br Results br Discussion Drug resistance poses

  2019-11-12

  

  Results Discussion Drug resistance poses the greatest hurdle of achieving high efficacy with AADs in cancer patients. AAD-treated cancer patients often encounter intrinsic and evasive drug resistance that diminishes the therapeutic efficacy to only minor survival benefits in most cancer types.

• br Acknowledgements br Introduction Water and electrolytes c

  2019-11-12

  

  Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and cisapride receptor governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of channel proteins in canc

• br Conclusions br Acknowledgement Grant

  2019-11-12

  

  Conclusions Acknowledgement Grant support: Ministry of Health (n. of grant: RBAP10447J_004 to N. Baldini), Italian Association for Cancer Research (n. of grant: 11426 to N. Baldini). Introduction Ewing sarcomas (ES) and primitive neuroectodermal tumors (PNET) are related childhood tumors.

• Busulfan Enlarging the ligand binding pocket by reduction of

  2019-11-12

  

  Enlarging the ligand-binding pocket by reduction of the size of the residue F435 switched DES to an agonist indicating that F435 is involved in mediating the antagonistic effect of DES (Fig. 7E) [13]. The conformation of the smaller side chain of L435 was either not altered by DES or was too small t

15557 records 928/1038 page Previous Next First page 上5页 926927928929930 下5页 Last page