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The term myeloproliferative disorders was first proposed by
2020-07-28
The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myeloproliferative dis
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MEN Montelukast Zafirlukast and Pranlukast antagonized leuko
2020-07-28
MEN91507, Montelukast, Zafirlukast, and Pranlukast antagonized leukotriene D4-induced bronchoconstriction in guinea-pigs, following both intravenous and oral administration. When administered intravenously, MEN91507 was the most potent amongst the CysLT1 receptor antagonists tested, since the ED50s
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lomitapide In vertebrates PAH AhR CYP A
2020-07-28
In vertebrates, PAH-AhR-CYP1A axis has been well established. AhR-dependent transcriptional modulation is caused by the xenobiotic response lomitapide (XRE) located on its promoter sequences (Jeong and Kim, 2002). In few invertebrates, presence of AhR has been reported in arthropods, nematodes, moll
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Previous studies reported that NE and MHPG are
2020-07-28
Previous studies reported that NE and MHPG are deeply involved in depression and that NE reuptake inhibitors are approved for use in patients with depression (for review, see [2]). We found increased hippocampal content of NE and MHPG in the CORT-treated CRTH2−/− mice (Fig. 3). In the hippocampus, a
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Alternatively procedural factors may have contributed to the
2020-07-28
Alternatively, procedural factors may have contributed to the conflicting results. For instance, in order to have a more circumscribed area of drug diffusion, a volume of 0.05μl was injected in experiment 1b, which is four times lower than the one used in the mentioned plus-maze investigation. Besid
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CPG a metalloenzyme derived from
2020-07-28
CPG2, a metalloenzyme derived from sp., was the elected enzyme for the first pilot-scale clinical trial of ADEPT. This enzyme has no mammalian homologue and activates glutamic CGP 42112 synthesis prodrug derivatives of several nitrogen mustards alkylating agents., , , , , A bond cleavable by CPG2
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Additional changes in the environment relate to
2020-07-28
Additional changes in the environment relate to the content and format of the CPA exam. In 2004, the exam switched to a computerized format, and students became able to pursue each of the four parts separately, affecting pass rates positively. All four parts must be passed within an 18-month interva
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With regard to neuroticism anxiety we did not find
2020-07-28
With regard to neuroticism/anxiety we did not find any direct associations with conditioned fear responses, which converges with a series of previous studies (Fredrikson and Georgiades, 1992, Grillon et al., 2006, Joos et al., 2012, Lommen et al., 2010, Martínez et al., 2012, Otto et al., 2007, Pine
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Understanding the nature of protein collagen interactions is
2020-07-27
Understanding the nature of protein–collagen interactions is also crucial in developing biomaterials that replicate the structural and biological characteristics of collagen [140]. These biomaterials can then be applied to develop scaffolds or tissues that can be valuable in surgeries or medicine [7
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Genomic DNA isolation Protist cells were digested
2020-07-27
Genomic DNA isolation. Protist cells were digested at 37°C for at least 1h with g/ml proteinase K in the presence of 10mM Tris–HCl, pH 8, 0.1M EDTA, 0.5% SDS, and g/ml DNAse-free RNAse. Samples were then subjected to extraction with phenol:chloroform followed by centrifugation. This procedure was re
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br Materials and methods br Results
2020-07-27
Materials and methods Results Table 1 shows the clinical data of the 63 recipients. They comprised 23 recipients with CYP3A5*1 allele (CYP3A5*1/*1 or *1/*3) and 40 recipients without CYP3A5*1 allele (CYP3A5*3/*3). Plasma concentration (mean ± SD) of 4β-hydroxycholesterol was 36.4 ± 11.7 ng/mL;
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5 03 To confirm and extend those
2020-07-27
To confirm and extend those findings of a differential interaction between hCrm1 and mCrm1 and Rev-RRE, we first attempted to use the yeast two and three hybrid systems, but failed to observe a detectable interaction between any of the Crm1s and Rev, in the presence or absence of HIV RRE RNA. We the
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br Funding This study was
2020-07-27
Funding This study was financially supported by the Defence Research and Development Organization (DRDO), Ministry of Defence, India (DIP-263). The first author, Garima Chauhan, is the recipient of a fellowship from the University Grant Commission (UGC), India. G. Kumar and P. Kumari recieved fel
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Of CE ribotyping profiles were recognized only
2020-07-27
Of 53 CE-ribotyping profiles, 24 were recognized only by the WEBRIBO database and these isolates comprised 11.2% (n=247) of our collection. The occurrence of several WRTs identified in our study (209, 220, 404, 416, 438, 500, 555, AI-12, AI-20, AI-21, AI-75, AI-9-1) has been reported as human clinic
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IFN-gamma, murine recombinant synthesis br Conclusion br Ack
2020-07-25
Conclusion Acknowledgements This work is supported by the National Natural Science Foundation of China (41806151, 41706144), the National Natural Science Foundation of China (31330082). We would like to thanks the support of young science and technology talents training fund of South China Agr
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