• The galactosidase from Aspergillus oryzae is a monomeric

  2022-01-06

  

  The β-galactosidase from Aspergillus oryzae is a monomeric enzyme of 113 kDa [58] that has been widely used in GOS synthesis [49,53,[59], [60], [61]], exhibiting a high activity of lactose transgalactosylation [62]. Different immobilization methods have been used for the synthesis of lactose-derived

• protein phosphatase At present many methods have been applie

  2022-01-06

  

  At present, many methods have been applied for multiple detection. For example, protein phosphatase [[9], [10], [11]] is frequently used to detect multiple targets because of its exquisite sensitivity and specificity, but it is difficult to design experiments to test short-length oligonucleotides. E

• In this work we constructed

  2022-01-06

  

  In this work, we constructed a versatile platform based on MoS2-loaded molecular beacon(MB) and HCR for miRNA detection with high sensitivity and low-background. In this method, the G-quadruplex/Thioflavin T (THT) as fluorescent signal output, which possesses a variety of advantages, such as label-f

• The current gold standard for

  2022-01-06

  

  The current gold standard for diagnosing BAM or BAD is the measurement of BA turnover rate with radiolabelled tauroselcholic (75selenium) substance p mg (also known as the SeHCAT retention test). SeHCAT test involves the use of a synthetic analogue of naturally occurring conjugated taurocholic acid

• uPAR promotes cell associated proteolysis by binding to uPA

  2022-01-06

  

  uPAR promotes cell-associated proteolysis by binding to uPA which locally converts plasminogen into active plasmin [10]. Ligand-engaged uPAR also acts as a potent regulator of cell migration and matrix attachment. Being a membrane receptor, uPAR needs to interact with extracellular matrix (ECM) prot

• Several transgenic and knockout congenic mouse models have b

  2022-01-06

  

  Several transgenic and knockout/congenic mouse models have been generated in order to assess the role of FFAR1 for proper insulin secretion and maintenance of glucose homeostasis. The results obtained with three different receptor knockout mouse models were not consistent. The protection against hig

• Several lines of evidences suggest that

  2022-01-06

  

  Several lines of evidences suggest that the biological features of PCs are different from other CLL/SLL BMN673 in the lymph node: the tumor cells in the PCs have been shown to accumulate cytogenetic abnormalities [1, 4] and aberrant expression of oncogene and tumorsuppressor microRNAs (miRs) [5, 6].

• br Main Text Post translational modifications including acet

  2022-01-06

  

  Main Text Post-translational modifications including acetylation, methylation, phosphorylation, and ubiquitination, of core histones directly alter DNA-histone and histone-histone interactions and thus influence nucleosome dynamics. Tight regulation of these marks is required by cells for proper

• Migration chemotaxis and trafficking of

  2022-01-06

  

  Migration, chemotaxis and trafficking of leukocytes, including eosinophils from the peripheral blood into the site of inflammation requires their adhesion to endothelial Chlorothiazide (Ley et al., 2007). Despite ongoing research, the histamine effect on eosinophils adhesion to endothelium cells ha

• br Acknowledgments br Introduction Myelin

  2022-01-05

  

  Acknowledgments Introduction Myelin, one of the fundamental adaptations of vertebrates, is a multilamellar structure deriving from the spiral wrapping around the Closantel Sodium mg of the plasma membrane of myelin forming glia, oligodendrocytes in the central nervous system and Schwann cells

• Acknowledgments This research was supported by the Korea Res

  2022-01-05

  

  Acknowledgments This research was supported by the Korea Research Institute of Chemical Technology (KRICT) funded by the Ministry of Science, ICT & Future Planning (KK1703-G00, KK1707-C05, SI1707-02, KK-1607-C09, and SKO1707C05) and a grant of the Korea Health Technology R&D Project through the Kor

• Although we showed that RBL H Sc cells took up

  2022-01-05

  

  Although we showed that RBL-2H3 Sc98 following website took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter family, includ

• In order to elucidate the reasons

  2022-01-05

  

  In order to elucidate the reasons of high efficacy of , we evaluated the BOC group itself and the linkage between the BOC group and the benzene ring of A-part. Urea moiety (), the replacement of an oxygen pka of alcohol of the BOC group to a nitrogen atom, decreased the activity (EC = 0.12 μM), whi

• Consistent with recent independent studies we confirm

  2022-01-05

  

  Consistent with recent independent studies, we confirm that the GCG-induced increase in oxygen consumption is only partially blunted in Fgf21−/− mice [32], implicating additional GCGR-dependent mechanisms contributing to the acute GCG-dependent enhancement of energy expenditure. Notably, glucagon ad

• Reports described a range of synthetic GPR

  2022-01-05

  

  Reports described a range of synthetic GPR40 agonists with desirable safety and efficacy profiles, compared with existing antidiabetic therapies such as insulin and sulfonylureas [[20], [21], [22], [23], [24], [25], [26], [27], [28]]. Among them, several small molecules were tested in the clinical t

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