• In the phase AZURE trial women were randomly assigned to

  2019-06-14

  

  In the phase 3 AZURE trial, 3360 women were randomly assigned to receive standard adjuvant systemic treatment alone (control group) or with 4mg intravenous zoledronic Dorsomorphin every 3–4 weeks for 6 doses, then every 3 months for 8 doses, followed by every 6 months for 5 doses, for a total of 5

• On behalf of the Japanese Heart Rhythm Society JHRS

  2019-06-14

  

  On behalf of the Japanese Heart Rhythm Society (JHRS), I am pleased to announce that we JHRS are merged with the Japanese Society of Electrocardiology (JCE) in 2015. Both societies have about 30-year history since their establishments, and have contributed to the development of sciences, education a

• Early repolarization is often also observed in Brugada syndr

  2019-06-14

  

  Early repolarization is often also observed in Brugada syndrome patients [30–34]. In this study, 34% of Brugada syndrome patients exhibited early repolarization in inferolateral leads. Clinical characteristics, inducibility, and arrhythmic event rate were similar between patients with and without ea

• Programmed death ligand PD L expression is a

  2019-06-14

  

  Programmed death ligand 1 (PD-L1) expression is a characteristic feature of EBV-associated malignancies. Research has shown that an increase of PD-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma. Preliminary data from a phase Ib study, KEYNOTE-028, showe

• One week after the CCRT

  2019-06-14

  

  One week after the CCRT, she was brought to our emergency department due to fever, severe general weakness, and severe oral pain. Her Sicca syndrome-related xerostomia had worsened due to radiotherapy and was complicated with severe stomatitis, which made oral intake difficult. She took traditional

• br In mid close to the

  2019-06-14

  

  In mid-2015, close to the finish line of the Millennium Development Goals (MDGs), Tanzania has reason to be proud. As Hoviyeh Afnan-Holmes and colleagues note in their Countdown to 2015 case study, Tanzania is on track to achieve MDG4: a two-thirds glp-2 in child mortality. The largest gains in s

• Studies using fixed site monitoring data rather than

  2019-06-14

  

  Studies using fixed-site monitoring data rather than personal monitoring data are subject to misclassification of the exposure because fixed site monitors do not account for individual mobility that affect exposure. Although, this typically results in non-differential exposure misclassification that

• Finally the effects of In NLS CSL on hematopoietic

  2019-06-13

  

  Finally, the effects of 111In-NLS-CSL360 on hematopoietic function in healthy Balb/c mice was studied. Groups of 2–4 mice were injected i.v. with 6.1±1.4MBq, 18.8±1.5MBq or 35.8±0.9MBq of 111In-NLS-CSL360 or an equivalent mass (70μg) of unlabeled CSL360 or received normal saline. At two weeks post-t

• br Discussion Sato et al first reported TCM in and

  2019-06-13

  

  Discussion Sato et al. [11] first reported TCM in 1990, and thereafter, numerous cases were reported in the late 2000s. In 85% of the cases, TCM onset was preceded by an emotional or physical stress event, however, in 15% of the cases, the presence of a stress trigger could not be detected [2]. M

• We observed a downregulation of

  2019-06-13

  

  We observed a downregulation of several thyroid-related genes such as DUOX1, DUOX2, TG, and TSHR. This may appear counterintuitive given that dedifferentiation typically worsens patient outcomes. However, it is noteworthy that there was no difference in the calcifediol of SLC5A5 (sodium-iodide symp

• Introduction Tumor metastases of the skeleton occur

  2019-06-13

  

  Introduction Tumor metastases of the skeleton occur in up to 80% of patients in progressed stages of cancer, most commonly in cases of breast, lung, prostate, kydney and thyroid tumors [1,2]. Bone metastases are often associated with pathologic fractures, hypercalcemia and spinal cord compression,

• Introduction The heart beat provides the mechanical force fo

  2019-06-13

  

  Introduction The heart beat provides the mechanical force for the pumping of oxygenated blood to, and deoxygenated blood away from, the peripheral tissues [1]. This depends critically on the orderly activation and recovery of electrical excitation through the myocardium. Disruptions of this can lea

• br Conclusions br Conflict of interest br

  2019-06-13

  

  Conclusions Conflict of interest Introduction Arrhythmogenic right ventricular cardiomyopathy (ARVC), previously called arrhythmogenic right ventricular dysplasia (ARVD), is an inherited disease characterized by right ventricular degeneration and ventricular arrhythmias. ARVC is one of the

• NCT-501 Tuberculosis case finding and diagnostics are far fr

  2019-06-13

  

  Tuberculosis case-finding and diagnostics are far from perfect. The worldwide case detection rate of tuberculosis has stagnated at around 60%, not reaching the target of 70% originally set for 2000 but postponed to 2005, and then judged to be unreachable. In sub-Saharan Africa, case detection rates

• El tenor de aquella declaratoria se escribi con estas palabr

  2019-06-13

  

  El tenor de aquella declaratoria se escribió con estas palabras: De este modo, y al margen de otras consideraciones que pudieran hacerse al respecto, para el caso que nos ocupa es importante significar que la iniciativa mexicana acabó tapiando las puertas de la onu buy PLX4032 la España franquista,

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